Author(s):

• Mohammed Tarique
• Nezar Mohammed Boreak

Description:

This book provides an overview of the latest advancements in the use of (three-dimensional) 3D organoids and stem cells for regenerative endodontics. It begins with an introduction to the foundational techniques for 3D organoid culture and explores cutting-edge developments in 3D bioprinting specifically tailored for dental applications. The book further examines the role of organoids in drug screening, toxicity testing, and the modulation of immune responses. It discusses the role of the microenvironment in organoid development, detailing how biophysical and biochemical factors, along with engineered niches, can influence the growth and functionality of organoids. The book reviews the use of various types of stem cells in regenerative endodontic therapies. The book explores the complex cellular and molecular interactions within organoid cultures, including stem cell-macrophage crosstalk and key signaling pathways involved in tissue regeneration. The role of the extracellular matrix (ECM) and different types of scaffolds, including nanofibrous, injectable scaffolds, bioinks, and decellularized extracellular matrices, are discussed for their importance in supporting 3D organoid integration and biocompatibility.

ISBN: 9781032964584
e-Book ISBN: 9781003589921
Published Date: 2027
Page Count: 201 , File Size: 7 Mb